Even at levels 100X lower than those associated with its cancer causing effects, the presence of dioxin can cause immune system damage, severe reproductive and developmental problems, and interference with regulatory hormones.The Endometriosis Research Center (ERC) has testified before the California State Legislature concerning Assembly Bill 2820 [Cardoza, D-Merced] that, "feminine hygiene products (i.e. Dioxin, in turn, is a well-documented catalyst for Endometriosis - and the effects of Dioxin are cumulative; able to be measured as much as 20 or 30 years after exposure." The ERC also references an independent study that found, in an assessment of four brands of tampons and four brands of baby diapers, dioxins "were present at detectable concentrations in all samples." The presence of this toxin in tampons may be linked to endometriosis because dioxins last a long time in the body; they are chemically stable and can be absorbed by fat tissue, where they are then stored in the body.Their half-life in the body is estimated to be 7 to 11 years.
Mutagenic effects have been established for some lower chlorinated chemicals such as 3-chlorodibenzofuran, which is neither persistent nor an AH receptor agonist.
The symptoms reported to be associated with dioxin toxicity in animal studies are incredibly wide-ranging, both in the scope of the biological systems affected and in the range of dosage needed to bring these about.
Dioxins have different toxicity depending on the number and position of the chlorine atoms.
Because dioxins refer to such a broad class of compounds that vary widely in toxicity, the concept of toxic equivalency factor (TEF) has been developed to facilitate risk assessment and regulatory control.
The toxicity is mediated through the interaction with a specific intracellular protein, the aryl hydrocarbon (AH) receptor, a transcriptional enhancer, affecting a number of other regulatory proteins.
Abortion For And Against Essay - Dioxin Research Paper
This receptor is a transcription factor which is involved in expression of many genes.
The main characteristics of dioxins are that they are virtually insoluble in water but have a high affinity for lipids.
In addition, they tend to associate with organic matter, such as ash, soil, and plant leaves.
Toxic equivalence factors (TEFs) exist for seven congeners of dioxins, ten furans and twelve PCBs.
The reference congener is the most toxic dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) which per definition has a TEF of one.