Atorvastatin Thesis

Atorvastatin Thesis-27
Potency is thought to correlate to tissue permeability as the more lipophilic statins such as atorvastatin are thought to enter endothelial cells by passive diffusion, as opposed to hydrophilic statins such as pravastatin and rosuvastatin which are taken up into hepatocytes through OATP1B1 (organic anion transporter protein 1B1)-mediated transport. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. To investigate the efficacy and the safety of the three most commonly prescribed statins (rosuvastatin, atorvastatin, and pravastatin) for managing dyslipidemia among diabetic patients in Qatar. This retrospective observational population-based study included 350 consecutive diabetes patients who were diagnosed with dyslipidemia and prescribed any of the indicated statins between September 2005 and September 2009.More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-Co A) Reductase, which catalyzes the conversion of HMG-Co A to mevalonic acid.

Potency is thought to correlate to tissue permeability as the more lipophilic statins such as atorvastatin are thought to enter endothelial cells by passive diffusion, as opposed to hydrophilic statins such as pravastatin and rosuvastatin which are taken up into hepatocytes through OATP1B1 (organic anion transporter protein 1B1)-mediated transport. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. To investigate the efficacy and the safety of the three most commonly prescribed statins (rosuvastatin, atorvastatin, and pravastatin) for managing dyslipidemia among diabetic patients in Qatar. This retrospective observational population-based study included 350 consecutive diabetes patients who were diagnosed with dyslipidemia and prescribed any of the indicated statins between September 2005 and September 2009.More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-Co A) Reductase, which catalyzes the conversion of HMG-Co A to mevalonic acid.

Tags: Essay On Banking Sector In PakistanWriting Contextual EssaysHe Tries Succeeds EssaysEssays Stress HealthRobert Smalls EssayCreative Writing Course Description

Atorvastatin and other drugs from the statin class of medications including lovastatin, pravastatin, rosuvastatin, fluvastatin, and simvastatin are considered first-line options for the treatment of dyslipidemia.

Increasing use of the statin class of drugs is largely due to the fact that cardiovascular disease (CVD), which includes heart attack, atherosclerosis, angina, peripheral artery disease, and stroke, has become a leading cause of death in high-income countries and a major cause of morbidity around the world.

To learn more or modify/prevent the use of cookies, see our Cookie Policy and Privacy Policy.

Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, 106 Zhongshan Road, Weilun Bldg.

Numerous epidemiological studies and randomized controlled trials have documented the association between elevated LDL-C levels with increased CVD risk in both diabetic and nondiabetic populations [8, 9].

Thus reducing LDL-C levels is the primary goal of therapy for diabetic dyslipidemia [5, 10].

Atorvastatin reduced LDL-C the most at a dose of 40 mg (22.8%), and pravastatin reduced LDL-C the most at a dose of 20 mg (20.3%).

All three statins were safe in relation to muscular and hepatic functions.

Future large-scale prospective studies are needed to confirm these results.

Diabetes is now commonly recognized as a “coronary heart disease risk equivalent” [1–4].

SHOW COMMENTS

Comments Atorvastatin Thesis

The Latest from allgames-online.ru ©